Article

Sequential enrichment at the nuclear periphery of H2A.Zac and H3K9me2 accompanies pluripotency loss in human embryonic stem cells

2020-02-16

Abstract excerpt

During the transition from pluripotency to a lineage-committed state, chromatin undergoes large-scale changes in structure to effect the required changes to the transcriptional program. This involves covalent modification of histone tails, replacement of histone variants, and alteration in the subnuclear position of genes, including associations with the nuclear periphery. Here, using high-resolution microscopy an...

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Literature Corpus work: b51e3309-b112-50b4-9703-db2f20baa7f4
DOI: 10.1101/2020.02.15.951103

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