Article

Molecular architecture of heterochromatin at the nuclear periphery of primary human cells

2025-04-10

Abstract excerpt

In eukaryotes, meters of DNA are packaged into micrometer scale nuclei. Nucleosomes, as the major organizational unit, have been extensively studied in vitro, yet the elaborate 3D structure of chromatin inside cells and its distinct multi-nucleosome arrangements remain poorly resolved. Here, we combine cryo-electron tomography with template matching, subtomogram averaging and molecular simulations to visualize nuc...

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Literature Corpus work: d8468609-d97a-5414-ae13-06ecdc8be9d4
DOI: 10.1101/2025.04.09.647790

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