Article

Lamins organize the global three-dimensional genome from the nuclear periphery

2017-10-31

Abstract excerpt

Lamins are structural components of the nuclear lamina (NL) that regulate genome organization and gene expression, but the mechanism remains unclear. Using Hi-C, we show that lamins maintain proper interactions among the topologically associated chromatin domains (TADs) but not their overall architecture. Combining Hi-C with fluorescence in situ hybridization (FISH) and analyses of lamina-associated domains (LADs...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c1ac0fa2-3c7e-538e-b81c-4c71a0c4c10c
DOI: 10.1101/211656

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Lamins organize the global three-dimensional genome from the nuclear peripheryDOI 10.1101/211656Read

An atlas of lamina-associated chromatin across twelve human cell types reveals an intermediate chromatin subtypeSemantic proximity Read

Distinct features of nucleolus-associated domains in mouse embryonic stem cellsSemantic proximity Read

Lamin A/C maintains genome topology and regulates transcriptional programs essential for virus-driven B cell activationSemantic proximity Read

Chromatin protein complexes involved in gene repression in lamina-associated domainsSemantic proximity Read

Mechanistic and Epigenetic Partitioning of Lamina-Associated Chromatin Revealed by a Genome-Wide Imaging ScreenSemantic proximity Read

Lamin C regulates genome organization after mitosisSemantic proximity Read

Context-Dependent and Gene-Specific Role of Chromatin Architecture Mediated by Histone Modifiers and Loop-extrusion MachinerySemantic proximity Read

The nuclear lamins: flexibility in function.Semantic proximity Read

Diverse lamin-dependent mechanisms interact to control chromatin dynamics. Focus on laminopathies.Semantic proximity Read

Nuclear lamins: key regulators of nuclear structure and activities.Semantic proximity Read

From lamins to lamina: a structural perspective.Semantic proximity Read

Nuclear Lamins: Thin Filaments with Major Functions.Semantic proximity Read