Article

STAT3 ameliorates cognitive deficits by positively regulating the expression of NMDARs in a mouse model of FTDP-17

2020-05-07

Abstract excerpt

<title>Abstract</title> <p>Background In tauopathies, the degree of neurodegeneration and memory impairment positively strongly correlates with the amount of abnormal tau aggregates. Recently, we found that human wild-type tau accumulation activated Signal Transduction and Activator of Transcription-1 (STAT1) to inhibit the transcription of genes coding for synaptic N-methyl-D-aspartate receptors (NMDARs). STAT3...

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Literature Corpus work: e76b744c-e451-549d-a30f-302b23d74d94
DOI: 10.21203/rs.3.rs-25793/v1

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STAT3 ameliorates cognitive deficits by positively regulating the expression of NMDARs in a mouse model of FTDP-17DOI 10.21203/rs.3.rs-25793/v1Read

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