Article
Molecular and behavioural abnormalities in the FUS-tg mice mimic frontotemporal lobar degeneration: Effects of old and new anti-inflammatory therapies.
Journal of cellular and molecular medicine - 1 Sept 2020
de Munter Johannes, Babaevskaya Diana, Wolters Erik Ch, Pavlov Dmitrii, Lysikova Ekaterina, V Kalueff Allan, Gorlova Anna, Oplatchikova Margarita, Pomytkin Igor A, Proshin Andrey, Umriukhin Aleksei, Lesch Klaus-Peter, Strekalova Tatyana
Abstract excerpt
Genetic mutations in FUS, a DNA/RNA-binding protein, are associated with inherited forms of frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). A novel transgenic FUS[1-359]-tg mouse line recapitulates core hallmarks of human ALS in the spinal cord, including neuroinflammation and neurodegeneration, ensuing muscle atrophy and paralysis, as well as brain pathomorphological signs of...
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