Article

Stat3 mediates Fyn kinase driven dopaminergic neurodegeneration and microglia activation

2024-07-09

Abstract excerpt

The Alzheimer’s Disease and Parkinson’s Disease risk locus Fyn kinase is implicated in neurodegeneration and inflammatory signaling. To investigate in vivo mechanisms of Fyn driven neurodegeneration, we built a zebrafish neural specific Gal4:UAS model of constitutively active FynY531F signaling. Using in vivo live imaging we demonstrate neural FynY531F expression lead to dopaminergic neuron loss and mitochondria...

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Literature Corpus work: b12f72d5-3ec6-5558-9568-9e826eec0120
DOI: 10.1101/2024.07.05.602238

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