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Neural stem cell transplantation alleviates functional cognitive deficits in a mouse model of tauopathy

11 Jun 2021

Abstract excerpt

The mechanisms of the transplantation of neural stem cells (NSCs) in the treatment of Alzheimer's disease remain poorly understood. In this study, NSCs were transplanted into the hippocampal CA1 region of the rTg (tau P301L) 4510 mouse model, a tauopathy model that is thought to reflect the tau pathology associated with Alzheimer's disease. The results revealed that NSC transplantation reduced the abnormal...

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PMID: 34100451
DOI: 10.4103/1673-5374.314324

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