Article

Association of cerebellar inflammation and neurodegeneration in a novel spinocerebellar ataxia type 13 mouse model

2024-10-28

Abstract excerpt

<h4>Background</h4> Neuroinflammation is a recognized pathological characteristic of neurodegenerative diseases. Spinocerebellar ataxia 13 (SCA13) is a progressive neurodegenerative disease with no effective treatments. Our previous studies reported human mutations in KCNC3 gene are causative for SCA13. Human R423H allelic mutation induces early-onset neurodegeneration and aberrant intracellular retention of Epi...

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Literature Corpus work: d44e1549-87d9-52e2-9975-5885af5c59ed
DOI: 10.1101/2024.10.28.620701

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