Article

Neuronal PARIS-STAT3 axis drives tau pathology and glial activation in Alzheimer’s disease

2025-12-10

Abstract excerpt

PARIS, a substrate of Parkin, accumulates in Parkinson’s disease and promotes disease progression. Here, we demonstrate that PARIS also contributes to Alzheimer’s disease by elevating STAT3 transcriptional activity, thereby inducing tau pathology, hippocampal atrophy, and glial activation. Genetic depletion of Paris reduced tau phosphorylation and cognitive decline in tauopathy mice, whereas neuron-specific PARI...

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Literature Corpus work: bc7be8f2-b5c8-51b5-929e-232ea3687322
DOI: 10.64898/2025.12.06.692741

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