Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Acute tau knockdown in the hippocampus of adult mice causes learning and memory deficits

10 May 2018

Abstract excerpt

Misfolded and hyperphosphorylated tau accumulates in several neurodegenerative disorders including Alzheimer's disease, frontotemporal dementia with Parkinsonism, corticobasal degeneration, progressive supranuclear palsy, Down syndrome, and Pick's disease. Tau is a microtubule-binding protein, and its role in microtubule stabilization is well defined. In contrast, while growing evidence suggests that tau is also...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Neuroinflammation and Neurodegeneration Mechanisms
Share to Neuroscience and Neuropharmacology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29749079
DOI: 10.1111/acel.12775

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Acute tau knockdown in the hippocampus of adult mice causes learning and memory deficitsPMID 29749079Read ↗

Viral Delivery of Non-Mutated Human Truncated Tau to Neurons Recapitulates Key Features of Human Tauopathy in Wild-Type Mice.Semantic proximity Read ↗

Age-Dependent Neurofibrillary Tangle Formation, Neuron Loss, and Memory Impairment in a Mouse Model of Human Tauopathy (P301L)Semantic proximity Read ↗

Tau deposition drives neuropathological, inflammatory and behavioral abnormalities independently of neuronal loss in a novel mouse modelSemantic proximity Read ↗

Reducing tau ameliorates behavioural and transcriptional deficits in a novel model of Alzheimer’s diseaseSemantic proximity Read ↗

Lessons from Tau-Deficient MiceSemantic proximity Read ↗

Huntingtin is essential for synaptic plasticity in the adult hippocampusSemantic proximity Read ↗

Microtubule-associated protein tau is essential for long-term depression in the hippocampusSemantic proximity Read ↗

Tau is required for progressive synaptic and memory deficits in a transgenic mouse model of α-synucleinopathySemantic proximity Read ↗

Alzheimer's disease-like tau neuropathology leads to memory deficits and loss of functional synapses in a novel mutated tau transgenic mouse without any motor deficits.Semantic proximity Read ↗

Age-dependent axonal transport and locomotor changes and tau hypophosphorylation in a "P301L" tau knockin mouse.Semantic proximity Read ↗

Adult-onset focal expression of mutated human tau in the hippocampus impairs spatial working memory of rats.Semantic proximity Read ↗

Early-onset cognitive deficits and axonal transport dysfunction in P301S mutant tau transgenic mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.