Article

Pyruvate kinase M1 suppresses development and progression of prostate adenocarcinoma

2021-05-10

Abstract excerpt

<h4>ABSTRACT</h4> Most cancers, including prostate cancers, express the M2 splice isoform of pyruvate kinase ( Pkm2 ). This isoform can promote anabolic metabolism to support cell proliferation; however, Pkm2 expression is dispensable for many cancers in vivo . Pyruvate kinase M1 ( Pkm1 ) isoform expression is restricted to relatively few tissues and has been reported to promote growth of select tumors, but t...

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Literature Corpus work: e76669d6-1e72-56cf-8623-a4a3a282b867
DOI: 10.1101/2021.05.09.443334

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