Article
PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells.
Cell - 10 Oct 2013
Israelsen William J, Dayton Talya L, Davidson Shawn M, Fiske Brian P, Hosios Aaron M, Bellinger Gary, Li Jie, Yu Yimin, Sasaki Mika, Horner James W, Burga Laura N, Xie Jianxin, Jurczak Michael J, DePinho Ronald A, Clish Clary B, Jacks Tyler, Kibbey Richard G, Wulf Gerburg M, Di Vizio Dolores, Mills Gordon B, Cantley Lewis C, Vander Heiden Matthew G
Abstract excerpt
The pyruvate kinase M2 isoform (PKM2) is expressed in cancer and plays a role in regulating anabolic metabolism. To determine whether PKM2 is required for tumor formation or growth, we generated mice with a conditional allele that abolishes PKM2 expression without disrupting PKM1 expression. PKM2 deletion accelerated mammary tumor formation in a Brca1-loss-driven model of breast cancer. PKM2 null tumors displayed...
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