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Article

<i>Sleeping Beauty</i> screen reveals <i>Pparg</i> activation in metastatic prostate cancer

29 Jun 2016

Abstract excerpt

Prostate cancer (CaP) is the most common adult male cancer in the developed world. The paucity of biomarkers to predict prostate tumor biology makes it important to identify key pathways that confer poor prognosis and guide potential targeted therapy. Using a murine forward mutagenesis screen in a Pten-null background, we identified peroxisome proliferator-activated receptor gamma (Pparg), encoding a...

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Share to Cancer, Lipids, and Metabolism
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PMID: 27357679
DOI: 10.1073/pnas.1601571113

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