Article

MYBL2 drives prostate cancer plasticity and identifies CDK2 as a therapeutic vulnerability in RB1-loss and neuroendocrine prostate cancer

2024-02-02

Abstract excerpt

Phenotypic plasticity is a recognized mechanism driving therapeutic resistance in prostate cancer (PCa) patients. While underlying molecular causations driving phenotypic plasticity have been identified, therapeutic success is yet to be achieved. To identify putative master regulator transcription factors (MR-TF) driving phenotypic plasticity in PCa, this work utilized a multiomic approach using genetically engine...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cb4c81a6-138e-5314-a654-4de959dbda46
DOI: 10.1101/2024.01.31.578216

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

MYBL2 drives prostate cancer plasticity and identifies CDK2 as a therapeutic vulnerability in RB1-loss and neuroendocrine prostate cancerDOI 10.1101/2024.01.31.578216Read

Dynamic prostate cancer transcriptome analysis delineates the trajectory to disease progressionSemantic proximity Read

A single-cell and spatial atlas of prostate cancer reveals the combinatorial nature of gene modules underlying lineage plasticity and metastasisSemantic proximity Read

Epigenomics‐guided precision oncology: Chromatin variants in prostate tumor evolutionSemantic proximity Read

Dynamic prostate cancer transcriptome analysis delineates the trajectory to disease progression.Semantic proximity Read

Defining the combinatorial nature of gene modules in prostate cancer underlying lineage plasticity and metastasisSemantic proximity Read

LKB1 inactivation promotes epigenetic remodeling-induced lineage plasticity and antiandrogen resistance in prostate cancerSemantic proximity Read

ProMPt: A modular preclinical platform for functional modelling of prostate cancer heterogeneity and therapeutic vulnerabilitiesSemantic proximity Read

Lineage Plasticity and Stemness Phenotypes in Prostate Cancer: Harnessing the Power of Integrated “Omics” Approaches to Explore Measurable MetricsSemantic proximity Read

Distinct mesenchymal cell states mediate prostate cancer progressionSemantic proximity Read

Targeting Chromatin Effector Pygo2 to Enhance Immunotherapy in Prostate CancerSemantic proximity Read

The neuroendocrine transition in prostate cancer is dynamic and dependent on ASCL1Semantic proximity Read

Identification of potential therapeutic targets in prostate cancer through a cross-species approach.Semantic proximity Read