Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Role of PKM2 in Metabolic Reprogramming: Insights into the Regulatory Roles of Non-Coding RNAs.

International journal of molecular sciences - 25 Jan 2021

Puckett Dexter L, Alquraishi Mohammed, Chowanadisai Winyoo, Bettaieb Ahmed

Abstract excerpt

Pyruvate kinase is a key regulator in glycolysis through the conversion of phosphoenolpyruvate (PEP) into pyruvate. Pyruvate kinase exists in various isoforms that can exhibit diverse biological functions and outcomes. The pyruvate kinase isoenzyme type M2 (PKM2) controls cell progression and survival through the regulation of key signaling pathways. In cancer cells, the dimer form of PKM2 predominates and plays...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cellular Reprogramming
Share to Drug Development

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Evaluation, Preclinical

Share to Energy Metabolism

Share to Homeostasis

Share to Pyruvate Kinase

Share to RNA, Long Noncoding

Share to Thyroid Hormones

Source

Open in PubMed Open full text

Identifiers

PMID: 33503959
DOI: 10.3390/ijms22031171
PMCID: PMC7865720

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Role of PKM2 in Metabolic Reprogramming: Insights into the Regulatory Roles of Non-Coding RNAs.PMID 33503959Read ↗

Multiple functions of pyruvate kinase M2 in various cell typesSemantic proximity Read ↗

Oncoprotein CIP2A controls PKM2 dimer-tetramer transition through phosphorylation of serine 287 in non-small cell lung cancerSemantic proximity Read ↗

Elevating PKM2 Expression Indicates a Biomarker of Poor Prognosis in Patients With Liver CancerSemantic proximity Read ↗

PKM2 modulates chemotherapy sensitivity by regulating autophagy and predicts the prognosis and immunity in pancancerSemantic proximity Read ↗

The cysteine residue at 424th of pyruvate kinase M2 is crucial for tetramerization and responsiveness to oxidative stress.Semantic proximity Read ↗

Pyruvate Kinase M1 Suppresses Development and Progression of Prostate AdenocarcinomaSemantic proximity Read ↗

The Emerging Roles of the Metabolic Regulator G6PD in Human CancersSemantic proximity Read ↗

Discovery of functional alternatively spliced <i>PKM</i> transcripts in human cancersSemantic proximity Read ↗

The Multifarious Functions of Pyruvate Kinase M2 in Oral Cancer CellsSemantic proximity Read ↗

The biological role of metabolic reprogramming in pancreatic cancerSemantic proximity Read ↗

LncRNA YIYA enhances pancreatic cancer proliferation under high-glucose conditions through RAS–PKM2–mediated metabolic reprogramming that reinforces the Warburg phenotypeSemantic proximity Read ↗

The expression of PKM1 and PKM2 in developing, benign, and cancerous prostatic tissuesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.