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Article

Changes in PKM2 associate with prostate cancer progression.

Cancer investigation - 1 Aug 2014

Wong Nicholas, Yan Judy, Ojo Diane, De Melo Jason, Cutz Jean-Claude, Tang Damu

Abstract excerpt

Pyruvate kinase M2 (PKM2) is essential for aerobic glycolysis, the dominant metabolic pathway utilized by cancer cells. To determine the association of PKM2 with prostate cancer (PC), we examined 29 primary PC and three lymph node metastatic tumors; elevation of PKM2 was observed in Gleason 8-10 tumors compared to Gleason 6-7 carcinomas. High PKM2 was detected by immunohistochemistry in more aggressive xenograft...

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Source

Identifiers

PMID: 24884829
DOI: 10.3109/07357907.2014.919306

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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