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Article

Pyruvate Kinase M1 Suppresses Development and Progression of Prostate Adenocarcinoma

18 May 2022

Abstract excerpt

Abstract Altered metabolism helps sustain cancer cell proliferation and survival. Most cancers, including prostate cancers, express the M2 splice isoform of pyruvate kinase (PKM2), which can support anabolic metabolism to support cell proliferation. However, Pkm2 expression is dispensable for the formation and growth of many cancers in vivo. Expression of pyruvate kinase isoform M1 (Pkm1) is restricted to...

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PMID: 35584006
DOI: 10.1158/0008-5472.can-21-2352

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