Article

Computing the Human Interactome

2024-10-01

Abstract excerpt

Protein-protein interactions (PPI) are essential for biological function. Recent advances in coevolutionary analysis and Deep Learning (DL) based protein structure prediction have enabled comprehensive PPI identification in bacterial and yeast proteomes, but these approaches have limited success to date for the more complex human proteome. Here, we overcome this challenge by 1) enhancing the coevolutionary signals...

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Literature Corpus work: e0be7706-772b-5bbb-855f-79a162efa6c8
DOI: 10.1101/2024.10.01.615885

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