Article

Integrating computational protein structure predictions and genetic dependencies yields an atlas of human multi-protein complexes (AHMPC)

2025-09-12

Abstract excerpt

Knowledge of which proteins interact to form functional complexes in cells is essential for understanding molecular mechanisms in biology. Structure prediction methods recently allowed to compute the Human Interactome of likely binary protein interactions. We combine computational predictions with orthogonal functional data from the Dependency Map that estimate the correlation between genetic dependencies and vuln...

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Literature Corpus work: 58f4e904-5366-585c-9cb4-eba60e2790e2
DOI: 10.1101/2025.09.09.675133

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