Article

Induction of Recurrent Break Cluster Genes in Neural Progenitor Cells Differentiated from Embryonic Stem Cells In Culture

2019-12-30

Abstract excerpt

<h4>ABSTRACT</h4> Mild replication stress enhances appearance of dozens of robust recurrent genomic break clusters, termed RDCs, in cultured primary mouse neural stem and progenitor cells (NSPCs). Robust RDCs occur within genes (“RDC-genes”) that are long and have roles in neural cell communications and/or have been implicated in neuropsychiatric diseases or cancer. We sought to develop an in vitro approach to d...

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Literature Corpus work: e760d828-c0d9-5c03-a9f6-2dc3292851d0
DOI: 10.1101/2019.12.30.891168

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