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Article

Implication of E3 ligase RAD18 in UV-induced mutagenesis in human induced pluripotent stem cells and neuronal progenitor cells.

Journal of radiation research - 23 Mar 2023

Shimada Mikio, Tokumiya Takumi, Miyake Tomoko, Tsukada Kaima, Kanzaki Norie, Yanagihara Hiromi, Kobayashi Junya, Matsumoto Yoshihisa

Abstract excerpt

Pluripotent stem cells (PSCs) have the potential to differentiate to any of the other organs. The genome DNA integrity of PSCs is maintained by a high level of transcription for a number of genes involved in DNA repair, cell cycle and apoptosis. However, it remains unclear how high the frequency of genetic mutation is and how these DNA repair factors function in PSCs. In this study, we employed Sup F assay for...

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PMID: 36634340
DOI: 10.1093/jrr/rrac099
PMCID: PMC10036092

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