Article

Chromosome X Dosage Modulates Development of Aneuploidy in Genetically Diverse Mouse Embryonic Stem Cells

2024-07-03

Abstract excerpt

<h4>SUMMARY</h4> The genetic integrity of pluripotent stem cells (PSC) is critical to their applications in research and therapy, but it is compromised by frequent development of structural chromosome variants associated with malignancy. Many cell lines exhibit remarkable genetic stability, but little is known about the basis of the known variation in genomic integrity amongst different PSC isolates. Here we iden...

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Literature Corpus work: d34032bc-1022-5dd8-b999-1144e5f6ba19
DOI: 10.1101/2024.06.29.601344

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