Article
XRCC4 suppresses medulloblastomas with recurrent translocations in p53-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America - 9 May 2006
Yan Catherine T, Kaushal Dhruv, Murphy Michael, Zhang Yu, Datta Abhishek, Chen Changzhong, Monroe Brianna, Mostoslavsky Gustavo, Coakley Kristen, Gao Yijie, Mills Kevin D, Fazeli Alex P, Tepsuporn Suprawee, Hall Giles, Mulligan Richard, Fox Edward, Bronson Roderick, De Girolami Umberto, Lee Charles, Alt Frederick W
Abstract excerpt
Inactivation of the XRCC4 nonhomologous end-joining factor in the mouse germ line leads to embryonic lethality, in association with apoptosis of newly generated, postmitotic neurons. We now show that conditional inactivation of the XRCC4 in nestin-expressing neuronal progenitor cells, although leading to no obvious phenotype in a WT background, leads to early onset of neuronally differentiated medulloblastomas...
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