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DNA damage response in neurodevelopment and neuromaintenance

25 May 2022

Abstract excerpt

The central nervous system is particularly susceptible to DNA repair deficiency, which renders a variety of neurodevelopmental and neurodegenerative disorders in humans. It is generally believed that DNA damage occurs upon repetitive replication and oxidative stress in highly proliferating neuroprogenitor cells (NPs), or due to high rates of metabolism and active neuronal activity in terminally differentiated...

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PMID: 35612788
DOI: 10.1111/febs.16535

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