Article

Cas9-induced large deletions and small indels are controlled in a convergent fashion

2020-08-05

Abstract excerpt

Repair of Cas9-induced double-stranded breaks results primarily in formation of small indels, but can also cause potentially harmful large deletions. While mechanisms leading to the creation of small indels are relatively well understood, very little is known about the origins of large deletions. Using a novel library of clonal mouse embryonic stem cells bona fide deficient for 32 DNA repair genes, we have shown...

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Literature Corpus work: de23a494-4c4b-50e3-b0cf-af012c2df4bd
DOI: 10.1101/2020.08.05.216739

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