Article

Neuronal Enhancers are Hotspots For DNA Single-Strand Break Repair

2020-12-16

Abstract excerpt

Genome stability is essential for all cell types. However, defects in DNA repair frequently lead to neurodevelopmental and neurodegenerative diseases, underscoring the particular importance of DNA repair in long-lived post-mitotic neurons. The neuronal genome is subjected to a constant barrage of endogenous DNA damage due to high levels of oxidative metabolism in the central nervous system. Surprisingly, we know l...

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Literature Corpus work: e3f456d8-2d33-5893-aa9a-c2aacf4f76c7
DOI: 10.1101/2020.12.16.423085

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