Article

Endogenous neuronal DNA double-strand breaks are not sufficient to drive brain aging and neurodegeneration

2024-10-23

Abstract excerpt

<h4>ABSTRACT</h4> Loss of genomic information due to the accumulation of somatic DNA damage has been implicated in aging and neurodegeneration 1–3 . Somatic mutations in human neurons increase with age 4 , but it is unclear whether this is a cause or a consequence of brain aging. Here, we clarify the role of endogenous, neuronal DNA double-strand breaks (DSBs) in brain aging and neurodegeneration by generating...

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Literature Corpus work: 6384c321-6ac8-5c5a-a3bf-535458f388e5
DOI: 10.1101/2024.10.22.619740

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