Article

Type 1 interferon perturbates clonal competition by reshaping human blood development

2022-09-30

Abstract excerpt

Inflammation perturbs evolutionary dynamics of hematopoietic stem cell (HSC) clones in clonal hematopoiesis and myeloid neoplasms. We studied HSCs, progenitors and immune cells from patients with myeloproliferative neoplasm (MPN) at baseline and following interferon-⍺ (IFN⍺) treatment, the only MPN therapy to deplete clonal stem cells. We focused on essential thrombocythemia, an informative model of early-phase ne...

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Literature Corpus work: e74c0104-aff5-579d-9f78-12272084f956
DOI: 10.1101/2022.09.28.509751

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