Human TET2-Mutant Clonal Hematopoiesis Expansion Is Driven by Distinct Inflammatory Signaling Responses in Stem Cells Versus Myeloid Progeny.

doi:10.1158/2643-3230.BCD-25-0070

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Human TET2-Mutant Clonal Hematopoiesis Expansion Is Driven by Distinct Inflammatory Signaling Responses in Stem Cells Versus Myeloid Progeny.

Blood cancer discovery - 4 Mar 2026

Huerga Encabo Hector, D'Agostino Giuseppe, Sturgess Katherine, Lord Alice E, Jong Eric D, Ferrelli Alessandra, Sharma Aneesh, Mian Syed A, Habel Khadidja, Llorian-Sopena Miriam, Ramesh Amirtha Priya, Mohamad Nor Fatihah, Foissner Helene, Garcia-Albornoz Manuel, Graver Lynette, Papazoglou Despoina, Ngo Steven, Anjos-Afonso Fernando, Ariza-McNaughton Linda, Ficz Gabriella, Bonnet Dominique

Abstract excerpt

Clonal hematopoiesis (CH) increases with age and is associated with severe outcome in the course of infections or tumor development. Understanding the environmental conditions that favor mutant clones and the CH immune system response to such environments is key to designing therapeutic strategies to stall the expansion of mutant clones and the development of CH-associated pathologies. Using human cells, we...

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Identifiers

PMID: 41342736
DOI: 10.1158/2643-3230.BCD-25-0070
PMCID: PMC7618546

Genes

TET2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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