Article
Inflammatory cytokines promote clonal hematopoiesis with specific mutations in ulcerative colitis patients.
Experimental hematology - 1 Dec 2019
Zhang Christine R C, Nix Darren, Gregory Martin, Ciorba Matthew A, Ostrander Elizabeth L, Newberry Rodney D, Spencer David H, Challen Grant A
Abstract excerpt
Epidemiological sequencing studies have revealed that somatic mutations characteristic of myeloid neoplasms can be detected in the blood of asymptomatic individuals decades prior to presentation of any clinical symptoms. This premalignant condition is known as clonal hematopoiesis of indeterminate potential (CHIP). Despite the fact these mutant clones become readily detectable in the blood of elderly individuals...
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