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Article

Single-cell analyses reveal the clonal and molecular aetiology of Flt3L-induced emergency dendritic cell development.

Nature cell biology - 1 Mar 2021

Lin Dawn S, Tian Luyi, Tomei Sara, Amann-Zalcenstein Daniela, Baldwin Tracey M, Weber Tom S, Schreuder Jaring, Stonehouse Olivia J, Rautela Jai, Huntington Nicholas D, Taoudi Samir, Ritchie Matthew E, Hodgkin Philip D, Ng Ashley P, Nutt Stephen L, Naik Shalin H

Abstract excerpt

Regulation of haematopoietic stem and progenitor cell (HSPC) fate is crucial during homeostasis and under stress conditions. Here we examine the aetiology of the Flt3 ligand (Flt3L)-mediated increase of type 1 conventional dendritic cells (cDC1s). Using cellular barcoding we demonstrate this occurs through selective clonal expansion of HSPCs that are primed to produce cDC1s and not through activation of cDC1 fate...

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PMID: 33649477
DOI: 10.1038/s41556-021-00636-7

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