Article

Parallel Evolution of Leukemic Clones in Myeloproliferative Neoplasms

2025-11-17

Abstract excerpt

<title>Abstract</title> <p>Myeloproliferative neoplasms (MPNs) are hematological diseases predominantly driven by the JAK2V617F mutation. Progression from chronic-phase MPN to secondary acute myeloid leukemia (sAML) is a severe complication that dramatically worsens disease prognosis. While progression to sAML is classically linked to MPN clones acquiring additional cooperating mutations, the absence of the JAK2V...

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Literature Corpus work: 86319622-aa80-534e-8527-aa39f42f1710
DOI: 10.21203/rs.3.rs-8097141/v1

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