Inferring the dynamics of mutated hematopoietic stem and progenitor cells induced by IFNα in myeloproliferative neoplasms.

doi:10.1182/blood.2021010986

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Article

Inferring the dynamics of mutated hematopoietic stem and progenitor cells induced by IFNα in myeloproliferative neoplasms.

Blood - 2 Dec 2021

Mosca Matthieu, Hermange Gurvan, Tisserand Amandine, Noble Robert, Marzac Christophe, Marty Caroline, Le Sueur Cécile, Campario Hugo, Vertenoeil Gaëlle, El-Khoury Mira, Catelain Cyril, Rameau Philippe, Gella Cyril, Lenglet Julien, Casadevall Nicole, Favier Rémi, Solary Eric, Cassinat Bruno, Kiladjian Jean-Jacques, Constantinescu Stefan N, Pasquier Florence, Hochberg Michael E, Raslova Hana, Villeval Jean-Luc, Girodon François, Vainchenker William, Cournède Paul-Henry, Plo Isabelle

Abstract excerpt

Classical BCR-ABL-negative myeloproliferative neoplasms (MPNs) are clonal disorders of hematopoietic stem cells (HSCs) caused mainly by recurrent mutations in genes encoding JAK2 (JAK2), calreticulin (CALR), or the thrombopoietin receptor (MPL). Interferon α (IFNα) has demonstrated some efficacy in inducing molecular remission in MPNs. To determine factors that influence molecular response rate, we evaluated the...

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Identifiers

PMID: 34407546
DOI: 10.1182/blood.2021010986
PMCID: PMC8641097

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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