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Article

Chronic Interleukin-1 exposure triggers selective expansion of <i>Cebpa</i> -deficient multipotent hematopoietic progenitors

2020-03-26

Abstract excerpt

The early events that drive hematologic disorders like clonal hematopoiesis, myelodysplastic syndrome, myeloproliferative neoplasm, and acute myeloid leukemia are not well understood. Most studies focus on the cell-intrinsic genetic changes that occur in these disorders and how they impact cell fate decisions. We consider how chronic exposure to the pro-inflammatory cytokine, interleukin-1β (IL-1β), impacts Cebpa...

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Identifiers and source

Literature Corpus work
5c26e388-a0bb-587c-b04b-38a44901fb31
DOI
10.1101/2020.03.25.008250
Open publication

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Chronic Interleukin-1 exposure triggers selective expansion of <i>Cebpa</i> -deficient multipotent hematopoietic progenitorsDOI 10.1101/2020.03.25.008250
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