Article
Inherited resilience to clonal hematopoiesis by modifying stem cell RNA regulation.
Science (New York, N.Y.) - 1 Jan 2026
Agarwal Gaurav, Antoszewski Mateusz, Xie Xueqin, Pershad Yash, Arora Uma P, Poon Chi-Lam, Lyu Peng, Lee Andrew J, Guo Chun-Jie, Ye Tianyi, Norford Laila Barakat, Neehus Anna-Lena, Della Volpe Lucrezia, Wahlster Lara, Ranasinghe Diyanath, Ho Tzu-Chieh, Barlowe Trevor S, Chow Arthur, Schurer Alexandra, Taggart James, Durham Benjamin H, Abdel-Wahab Omar, McGraw Kathy L, Allan James M, Soldatov Ruslan, Bick Alexander G, Kharas Michael G, Sankaran Vijay G
Abstract excerpt
Somatic mutations that increase the fitness of hematopoietic stem cells (HSCs) drive their expansion in clonal hematopoiesis (CH) and predispose individuals to blood cancers. Population variation in the growth rate and potential of mutant clones suggests that genetic factors may confer resilience against CH. Here, we identified a noncoding regulatory variant, rs17834140-T, that protects against CH and myeloid...
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