Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Txnip Enhances Fitness of Dnmt3a -Mutant Hematopoietic Stem Cells via p21

8 Apr 2022

Abstract excerpt

Clonal hematopoiesis (CH) refers to the age-related expansion of specific clones in the blood system, and manifests from somatic mutations acquired in hematopoietic stem cells (HSCs). Most CH variants occur in the gene DNMT3A, but while DNMT3A-mutant CH becomes almost ubiquitous in aging humans, a unifying molecular mechanism to illuminate how DNMT3A-mutant HSCs outcompete their counterparts is lacking. Here, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Hematopoietic Stem Cell Transplantation
Share to Zebrafish Biomedical Research Applications

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35394496
DOI: 10.1158/2643-3230.bcd-21-0132

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Txnip Enhances Fitness of Dnmt3a -Mutant Hematopoietic Stem Cells via p21PMID 35394496Read ↗

Delayed Trp53 activation protects Dnmt3a-mutant hematopoietic stem cells from inflammatory attrition.Semantic proximity Read ↗

Chronic infection drives Dnmt3a-loss-of-function clonal hematopoiesis via IFNγ signaling.Semantic proximity Read ↗

Selective advantage of mutant stem cells in human clonal hematopoiesis is associated with attenuated response to inflammation and aging.Semantic proximity Read ↗

Transcriptomic alterations including p53 pathway dysregulation prime DNMT3A mutant cells for transformationSemantic proximity Read ↗

Tissue-Biased Expansion of DNMT3A-Mutant Clones in a Mosaic Individual Is Associated with Conserved Epigenetic Erosion.Semantic proximity Read ↗

Transcriptomic changes including p53 dysregulation prime DNMT3A mutant cells for transformation.Semantic proximity Read ↗

Aging-elevated inflammation promotes DNMT3A R878H-driven clonal hematopoiesisSemantic proximity Read ↗

Cellular stressors contribute to the expansion of hematopoietic clones of varying leukemic potentialSemantic proximity Read ↗

DNMT3A-R882 mutations intrinsically drive dysfunctional neutropoiesis from human haematopoietic stem cellsSemantic proximity Read ↗

Loss of Dnmt3a Immortalizes Hematopoietic Stem Cells In VivoSemantic proximity Read ↗

Proteostasis Stress Drives Stem Cell Aging, Clonal Hematopoiesis and LeukemiaSemantic proximity Read ↗

Epigenetic Guardian: A Review of the DNA Methyltransferase DNMT3A in Acute Myeloid Leukaemia and Clonal HaematopoiesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.