Article

EHMT2 Inactivation in Pancreatic Epithelial Cells Shapes the Transcriptional Landscape and Inflammation Response of the Whole Pancreas

2024-03-16

Abstract excerpt

<h4>ABSTRACT</h4> The Euchromatic Histone Methyl Transferase Protein 2 (EHMT2), also known as G9a, deposits transcriptionally repressive chromatin marks that play pivotal roles in the maturation and homeostasis of multiple organs. Recently, we have shown that EHMT2 inactivation alters growth and immune gene expression networks, antagonizing KRAS-mediated pancreatic cancer initiation and promotion. Here, we elucid...

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Literature Corpus work: c8e3593f-e8a8-5335-a45b-e7dabdbe11c5
DOI: 10.1101/2024.03.14.584700

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