Article

Chromatin alterations in the aging lung change progenitor cell activity

2021-07-15

Abstract excerpt

The lung contains multiple progenitor cell types that respond to damage, but how their responses are choreographed and why they decline with age is poorly understood. We report that histone H3 lysine 9 di-methylation (K9me2), mediated by histone methyltransferase G9a, regulates the dynamics of lung epithelial progenitor cells, and this regulation deteriorates with age. In aged mouse lungs, K9me2 loss coincided wit...

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Literature Corpus work: 4cb6178c-5c20-549e-942f-fc5ab8bc6a80
DOI: 10.1101/2021.07.15.452072

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