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Article

NNMT promotes tubular senescence and fibrosis in chronic kidney disease

2025-01-06

Abstract excerpt

<h4>ABSTRACT</h4> Chronic kidney disease (CKD) is a major global health issue, projected to become the fifth leading cause of mortality by 2040. Renal tubular cell senescence is a key driver of kidney fibrosis, the final manifestation of CKD. However, current treatment strategies, do not target senescent cells, as the underlying mechanisms driving this dysfunctional phenotype remain poorly described. Here, we ide...

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Identifiers and source

Literature Corpus work
e743c426-69e0-5cc7-863f-9db37054e199
DOI
10.1101/2025.01.06.631437
Open publication

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NNMT promotes tubular senescence and fibrosis in chronic kidney diseaseDOI 10.1101/2025.01.06.631437
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