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NAT10 mediates TLR2 to promote podocyte senescence in adriamycin-induced nephropathy

19 Mar 2025

Abstract excerpt

N-acetyltransferase 10 (NAT10) is involved in regulating senescence. However, its role in glomerular diseases remains unclear. Therefore, this study aims to investigate the mechanisms by which NAT10 influences senescence and damage in an adriamycin (ADR)-induced nephropathy model. Senescence (p16 and p21) and DNA damage markers (γ-H2AX (ser139)) were assessed in ADR-induced nephropathy. NAT10 function was...

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PMID: 40108127
DOI: 10.1038/s41419-025-07515-1

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