Article

<i>Srcap</i> Haploinsufficiency Induced Autistic-Like Behaviors in Mice through Disruption of <i>Satb2</i> Expression

2023-07-03

Abstract excerpt

Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with significant genetic predispositions. Among these, loss-of-function mutations of the chromatin remodeling gene SRCAP have been identified in individuals with ASD, but their pathogenic mechanisms have yet to be fully elucidated. In this study, we established a germline mutant mouse model harboring a heterozygous frameshift mutation in the...

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Literature Corpus work: e73c3201-a6a9-5a7a-91a6-6d320e650ad1
DOI: 10.1101/2023.07.03.547590

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