Article

Exposure to sevoflurane results in changes of transcription factor occupancy in sperm and inheritance of autism

2021-03-09

Abstract excerpt

<h4>ABSTRACT</h4> One in 54 children in the U.S. is diagnosed with Autism Spectrum Disorder (ASD). De novo germline and somatic mutations cannot account for all cases of ASD, suggesting that epigenetic alterations triggered by environmental exposures may be responsible for a subset of ASD cases. Human and animal studies have shown that exposure of the developing brain to general anesthetic (GA) agents can trigger...

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Literature Corpus work: 3ae94e08-f3fa-5135-9353-b12e7157054c
DOI: 10.1101/2021.03.08.434461

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