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Article

ASH1L haploinsufficiency results in autistic-like phenotypes in mice and links Eph receptor gene to autism spectrum disorder.

Neuron - 6 Apr 2022

Yan Yuze, Tian Miaomiao, Li Meng, Zhou Gang, Chen Qinan, Xu Mingrui, Hu Yi, Luo Wenhan, Guo Xiuxian, Zhang Cheng, Xie Hong, Wu Qing-Feng, Xiong Wei, Liu Shiguo, Guan Ji-Song

Abstract excerpt

ASD-associated genes are enriched for synaptic proteins and epigenetic regulators. How those chromatin modulators establish ASD traits have remained unknown. We find haploinsufficiency of Ash1l causally induces anxiety and autistic-like behavior, including repetitive behavior, and alters social behavior. Specific depletion of Ash1l in forebrain induces similar ASD-associated behavioral defects. While the learning...

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PMID: 35081333
DOI: 10.1016/j.neuron.2021.12.035

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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