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<i>Arid1b</i> haploinsufficiency in pyramidal neurons causes cellular and circuit changes in neocortex but is not sufficient to produce behavioral or seizure phenotypes

2024-06-05

Abstract excerpt

<h4>ABSTRACT</h4> Arid1b is a high confidence risk gene for autism spectrum disorder that encodes a subunit of a chromatin remodeling complex expressed in neuronal progenitors. Haploinsufficiency causes a broad range of social, behavioral, and intellectual disability phenotypes, including Coffin-Siris syndrome. Recent work using transgenic mouse models suggests pathology is due to deficits in proliferation, survi...

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Literature Corpus work
e0430b65-a2e7-540f-859b-db49cce8b23d
DOI
10.1101/2024.06.04.597344
Open publication

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<i>Arid1b</i> haploinsufficiency in pyramidal neurons causes cellular and circuit changes in neocortex but is not sufficient to produce behavioral or seizure phenotypesDOI 10.1101/2024.06.04.597344
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