Article

Loss of ASH1L in developing brains causes autistic-like behaviors in a mouse model

2020-11-16

Abstract excerpt

Autism spectrum disorder (ASD) is a neurodevelopmental disease associated with various gene mutations. Recent genetic and clinical studies report that mutations of the epigenetic gene ASH1L are highly associated with human ASD and intellectual disability (ID). However, the causal link between ASH1L mutations and ASD/ID remains undetermined. Here we show loss of ASH1L in developing mouse brains is sufficient to c...

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Literature Corpus work: 39d55c82-8bc9-5754-8bac-228219b4e1d4
DOI: 10.1101/2020.11.16.377259

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