Article

A mouse model of ATRX deficiency with cognitive deficits and autistic traits

2023-07-21

Abstract excerpt

<h4>ABSTRACT</h4> ATRX is an ATP-dependent chromatin remodeling protein with essential roles in safeguarding genome integrity and modulating gene expression. Deficiencies in this protein cause ATR-X syndrome, a condition characterized by intellectual disability and an array of developmental abnormalities, including features of autism. Previous studies demonstrated that deleting ATRX in mouse forebrain excitatory...

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Literature Corpus work: 0c21990d-b5ee-564b-b1bf-7bdbdb0fd30d
DOI: 10.1101/2023.07.19.549759

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