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Article

Epigenetic modulation rescues neurodevelopmental deficits in Syngap1+/− mice

29 Jan 2025

Abstract excerpt

Abstract SYNGAP1 is a Ras GTPase‐activating protein that plays a crucial role during brain development and in synaptic plasticity. Sporadic heterozygous mutations in SYNGAP1 affect social and emotional behaviour observed in intellectual disability (ID) and autism spectrum disorder (ASD). Although neurophysiological deficits have been extensively studied, the epigenetic landscape of SYNGAP1 mutation‐mediated...

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PMID: 39878322
DOI: 10.1111/acel.14408

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