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Cognitive and Synaptic Impairment Induced by Deficiency of Autism Risk Gene <i>Smarcc2</i> and its Rescue by Histone Deacetylase Inhibition

2025-05-30

Abstract excerpt

SMARCC2 , which encodes BAF170, a core subunit of chromatin remodeling BAF complex, is one of the top-ranking risk genes for autism spectrum disorder (ASD). However, the mechanisms linking SMARCC2 haploinsufficiency to ASD remain poorly understood. Genome-wide RNA-seq analysis revealed that SMARCC2 was significantly diminished in iPSC-derived neurons from idiopathic ASD patients. ChIP-seq of SMARCC2 demonstrate...

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Literature Corpus work
cb4ca26b-ce58-585e-b60f-6e84c4b4b496
DOI
10.1101/2025.05.29.656867
Open publication

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Cognitive and Synaptic Impairment Induced by Deficiency of Autism Risk Gene <i>Smarcc2</i> and its Rescue by Histone Deacetylase InhibitionDOI 10.1101/2025.05.29.656867
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