Targeting synaptic plasticity and acetylcholine dysregulation in the medial prefrontal cortex: Rosmarinic acid attenuates Autism-like phenotypes in Shank3B-/- mice via the CREB/BDNF pathway.

Abstract excerpt

RATIONALE: Autism spectrum disorder (ASD) is characterized by cognitive deficits, repetitive behaviors, and social impairments. The SH3 and multiple ankyrin repeat domains protein 3B-deficient (Shank3B-/-) mouse model displays ASD-related phenotypes. While rosmarinic acid (RosA) is known for its neuroprotective properties, its role in ASD remains unclear. OBJECTIVE: This study aimed to investigate the therapeutic...

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• Acetylcholine
• Autism Spectrum Disorder
• Brain-Derived Neurotrophic Factor
• Cinnamates
• Cyclic AMP Response Element-Binding Protein