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Article

Arid1b haploinsufficiency in parvalbumin- or somatostatin-expressing interneurons leads to distinct ASD-like and ID-like behavior.

Scientific reports - 12 May 2020

Smith Amanda L, Jung Eui-Man, Jeon Byeong Tak, Kim Woo-Yang

Abstract excerpt

Inhibitory interneurons are essential for proper brain development and function. Dysfunction of interneurons is implicated in several neurodevelopmental disorders, including autism spectrum disorder (ASD) and intellectual disability (ID). We have previously shown that Arid1b haploinsufficiency interferes with interneuron development and leads to social, cognitive, and emotional impairments consistent with ASD and...

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Identifiers

PMID: 32398858
DOI: 10.1038/s41598-020-64066-5
PMCID: PMC7217886

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